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Home Newsletters NL-1-2014-LETTER-17-A new compound developed for Depression -V.P.Laavanya
NL-1-2014-LETTER-17-A new compound developed for Depression -V.P.Laavanya PDF Print E-mail

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A new compound developed for Depression

V.P.Laavanya

B.Pharm II year,School of Pharmaceutical Sciences,Vels university

A compound developed for depression known as Hydroxynorketamine (HNK), without any side effect and associated with the psychoactive drug.

Irving Wainer, Ph.D and Baltimore said, that the clinical use of ketamine therapy for depression is limited because the drug is administered intravenously and may produce adverse effects such as hallucinations and sedation to the point of anesthesia

They have found that the HNK compound significantly contributes to the anti-depressive effects of ketamine in animals, without producing the sedation or anesthesia, which makes it an attractive alternative as an antidepressant in humans.


It was found that HNK, like ketamine, not only produced potent and rapid antidepressant effects, but also stimulated neuro-regenerative pathways.

HNK also appears to have several advantages over ketamine in that it is 1,000 times more potent, does not act as an anesthetic agent, and can be taken by mouth, the authors report.

Interestingly, use of HNK may also serve as a future therapeutic approach for treating neurodegenerative disorders such as Alzheimer's and Parkinson's diseases, the authors note.

 

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