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NL-1-2014-LETTER-5... OBESE MADE LEAN BY LEANS By:  S.Santhya.,(B-Pharm-Final Year)Vels University The Microbes from Lean People Act as Anti-Obesity Agents. Bugs that lurk in the guts of slim...


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Home Newsletters NL-1-2014-LETTER-5 -OBESE MADE LEAN BY LEANS By: S.Santhya
NL-1-2014-LETTER-5 -OBESE MADE LEAN BY LEANS By: S.Santhya PDF Print E-mail


By:  S.Santhya.,(B-Pharm-Final Year)Vels University

The Microbes from Lean People Act as Anti-Obesity Agents. Bugs that lurk in the guts of slim people could be turned into radical new therapies to treat obesity, according to a new study.

The claim follows a series of experiments which found that the different populations of bacteria that live in lean and overweight people caused mice to lose or gain weight.Scientists at Washington University School of Medicine in St Louis said that altering the number of microbes in the gut would serve as a useful tool in tackling obesity.


Researchers led by Jeffrey Gordon recruited four pairs of women who were twins. One woman in each pair was obese; the other had a healthy body weight.

The researchers collected faeces from each woman which contained a wealth of expelled gut microbes.

Scientists investigated what happened when they transplanted these into mice bred to have no gut microbes of their own.

The scientists found that mice stayed slim when they received faecal transplants from slim women, but put on much more fat when they received samples from the obese twin.Tests revealed that one type of bug, called Bacteroides, was more plentiful in slim women and protected the animals from putting on too much fat.

In a follow-up experiment, mice with microbes from the slim women shared a cage with mice that had microbes from obese women. Because of the animals' proclivity for coprophagia – that is their habit for eating each other’s poo – this caused a mixing of the animals' gut microbes.

After the mice had spent 10 days as cage mates, the obese ones had become leaner. But this happened in animals fed with a healthy diet that was high in fibre and low in saturated fats. When the diet was switched to high-fat, low-fibre meals the obese mice remained overweight.


The microbes extracted from the gut of lean persons can serve as a successful tool in treating obesity which can be there after maintained by a controlled diet.


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