ISSN: 2321 – 0494


News Flash

NL-1-2014-LETTER-1 CELLS...

www.ijfstonline.org CELLS IN LIVING MICE 'REPROGRAMMED' TO EMBRYONIC-LIKE STATE S. Sharmilabanu.,(B.Pharm Final Year), Vels university. Stem cells Stem cells are undifferentiated biological...

Read more...

NL-1-2014-LETTER-2 -...

www.ijfstonline.org BETTER ACTION ON WARFARIN ON YOUNGER HEART FAILURE PATIENTS   By:  Dhulipala Sowmya.,(B-Pharm II year),Vels University Warfarin may be more beneficial than aspirin in...

Read more...

...

  www.ijfstonline.org EFFECTS OF POLLUTION ON HUMAN HEALTH By:Rohin kumar.,(B-Pharm I Year)Vels Uuniversity The overview of main health effects on humans from some common types of pollution....

Read more...

NL-1-2014-LETTER-4...

www.ijfstonline.org PROGERIA By:  Prithivi Logathasan,(B-Pharm III Year),Vels University HGPS (Hutchinson-Gilford Progeria Syndrome) or Progeria is an extremely rare, fatal genetic condition....

Read more...

NL-1-2014-LETTER-5...

www.ijfstonline.org OBESE MADE LEAN BY LEANS By:  S.Santhya.,(B-Pharm-Final Year)Vels University The Microbes from Lean People Act as Anti-Obesity Agents. Bugs that lurk in the guts of slim...

Read more...

User Login



I2OR index

Who's Online

We have 12 guests online
Home Newsletters NL-1-2014-LETTER-1 CELLS IN LIVING MICE 'REPROGRAMMED' TO EMBRYONIC-LIKE STATE - Sharmila banu
NL-1-2014-LETTER-1 CELLS IN LIVING MICE 'REPROGRAMMED' TO EMBRYONIC-LIKE STATE - Sharmila banu PDF Print E-mail

www.ijfstonline.org

CELLS IN LIVING MICE 'REPROGRAMMED' TO EMBRYONIC-LIKE STATE

S. Sharmilabanu.,(B.Pharm Final Year), Vels university.

Stem cells

Stem cells are undifferentiated biological cells, that can differentiate into specialized cells and can divide (through mitosis) to produce more stem cells. They are found in multi cellular organisms. In adult organisms, stem cells and progenitor cells act as a repair system or the body, replenishing a adult tissue. In a developing embryo stem cells can differentiate into all the specialized cells – ectoderm, endoderm and mesoderm (see induced pluripotent stem cells) – but also maintain the normal turnover of regenerative organs, such as blood, skin or intestinal tissues.

Cells in a living animal can be reprogrammed into a more primitive, embryonic-like state, in which they are capable of transforming into any cell in the body, such cells, known as induced pluripotent stem cells (iPS), have been created before, but only by using lab dishes to grow them. The new study is the first to turn back the developmental clock on cells while they are inside a living organism — in this case, a mouse,the findings open up new possibilities for regenerative medicine, said study researcher Manuel Serrano, director of the Molecular Oncology Program at the Spanish National Cancer Research Center.

The researchers now need to determine whether iPS cells created in a living organism are capable of regenerating damaged tissue - a key step in determining their therapeutic potential.

Creating stem cells:

Embryonic stem cells can give rise to virtually any cell type in the body, such as skin or heart cells, so they are being investigated for their ability to treat illnesses. However, embryonic stem cells exist during only the first days of an embryo's development, so they cannot be found in adults.

In 2006, Shinya Yamanaka of Kyoto University in Japan showed that, by adding only four genes(oct,sox-2,klf4 and cMyc) adult cells in a lab dish could be transformed into

embryoniclike cells, so these cells were given the name "induced pluripotent stem cells." (Last year, Yamanaka received a Nobel Prize for the work.)

Manuel serrano

In the new study, Serrano and his colleagues achieved the same feat, but they didn't use a lab dish. The researchers created "reprogrammable mice," or genetically engineered mice in which the four genes found by Yamanaka could be "turned on" by a "switch." The switch, in this case, was exposure to a drug called doxycycline (an antibiotic).

When the mice drank water spiked with doxycycline, they developed teratomas in various tissues. Teratomas are tumors that originate from pluripotent cells, and contain the three main groups of cells formed during embryo development, although they are disorganized. The presence of teratomas in the mice indicated that the researchers had, indeed, turned back the clock on the mouse tissue cells.

When the researchers further analyzed the iPS cells that formed in the mice, they found that the cells had the ability to differentiate into not only body tissues, but also cells that form the placenta. Human embryos have this capability when they are 72 hours old, but it has never been replicated in a laboratory.

"This data tell us that our stem cells are much more versatile" than those created in a lab dish, the researchers said.

The first clinical trial to attempt to test lab-made iPS cells in people was approved in Japan in July, and aims to turn skin cells into retinal cells to treat age-related macular degeneration, which causes blindness.

The researchers of the new study noted that it took seven years from the discovery of iPS cells to begin the first clinical trial on people, and speculated that a similar amount of time may need to pass before in vivo iPS cells could be tested in people.This technology find its applications in repairing damaged spinal cord or make new insulin producing cells.

 

 

 

 

Latest News

Popular

Indexing

News Letter


© 2012 Internationaljournalofindiansciences.org. All Rights Reserved. Powered by JK Webdesigns.

Free Counters